BIRC2 and colorectal carcinoma: Treatment with ASTX660 alone displayed no cytotoxic effects in various CRC cell lines in doses up to 10 μm (Fig. 1A and Fig. S1), whereas ASTX660 concentrations as low as 40 nm were sufficient to decrease cIAP2 (but not cIAP1) levels rapidly (Fig. 1B,C).