In addition, we also crossed both lines with Xpg−/− mice, an additional DNA repair deficiency mouse model, with a highly similar life span and accelerated aging phenotype, that could also be substantially delayed by DR (Barnhoorn et al., 2014; Vermeij, Dollé, et al., 2016). The gene discussed is ERCC5; the disease is hyperinsulinemic hypoglycemia, familial, 4.