Following inhibition of STAT3 signalling using 5,15-diphenyl-porphine or the anti-IL-10R neutralization antibody, we observed obvious decreases in Sp1 expression on LECs and LEC attraction of M2-polarized THP-1 macrophages and tumour cells (SiHa) (Fig. S5C–E). The gene discussed is STAT3; the disease is neoplasm.