BRCA2 and hereditary breast ovarian cancer syndrome: Largely, HBOC syndrome results from germline mutations in breast cancer genes BRCA1 or BRCA2. In HBOC patients, an increased risk of other neoplasms including prostate cancer, pancreatic cancer, gastric cancer and cutaneous malignant melanoma, has been reported, especially in individuals with germline BRCA2 mutations [9].