Largely, HBOC syndrome results from germline mutations in breast cancer genes BRCA1 or BRCA2. In HBOC patients, an increased risk of other neoplasms including prostate cancer, pancreatic cancer, gastric cancer and cutaneous malignant melanoma, has been reported, especially in individuals with germline BRCA2 mutations [9]. This evidence concerns the gene BRCA2 and Hereditary breast and ovarian cancer syndrome.