Another patient P3 harbored variants in two genes namely POLG (p.Arg1187Trp) and SUCLG2 (p.Glu79*) reported to be associated with mitochondrial respiratory chain diseases and mtDNA depletion, impaired respiratory complex subunits and mitochondrial encephalopathy, respectively. The gene discussed is SUCLG2; the disease is Mitochondrial encephalopathy.