MAPT and tauopathy: Based on this, oligomeric tau species are now considered to play a central role in the pathogenesis of neuronal dysfunction in tauopathies (Ghag et al., 2018; Polanco et al., 2018; Sengupta et al., 2018; Bittar et al., 2019), comparable to oligomeric structures in other neurodegenerative disorders (Hong et al., 2018; Sekiya et al., 2019).