CYBB and myocardial infarction: In both human and murine macrophages, miR-106b-5p, miR-148b-3p, and miR-204-5p were shown to suppress NOX2 and targeted up-regulation of these miRNAs through pH-sensitive polyketal NP-specific delivery to macrophages significantly improved infarct size and cardiac function post-MI in mice, highlighting another potential therapeutic axis for management of MI86 (Figure 3A).