CYBB and atrial fibrillation: While a number of small clinical trials reported a reduction in the new onset of AF after cardiac surgery in patients allocated to perioperative statin therapy16, a much larger randomized controlled trial of perioperative statin therapy showed no discernible benefit of rosuvastatin on the incidence of AF after cardiac surgery,16 in keeping with our findings showing that inhibition of NOX2 activity by ATV does not lead to a reduction in pacing-induced AF in NOX2-Tg or WT.