PDHA2 and kidney disorder: In contrast to the chromosome 10 region, we are unable to find a plausible candidate gene within the chromosome 2 UPE locus despite the fact that it is only 0.2 Mb and contains a single gene, Pyruvate dehydrogenase E1 Alpha 2 subunit (Pdha2). This gene is involved in pyruvate metabolism and the Hif-1 signaling pathway (www.genecards.com), although no work has previously linked it to kidney disease.