To prove this, we first determined the effect of GABPA depletion on protein expression and phosphorylation of ERK in four cancer cell lines harboring both BRAFV600E and TERT promoter mutations, including melanoma cell line A375, thyroid cancer cell lines BCPAP and 8305C, and breast cancer cell line MDA-MB-231. The gene discussed is GABPA; the disease is breast carcinoma.