AKT1 and diffuse large B-cell lymphoma: To put this in context, HOTAIR promotes cell growth and inhibits apoptosis by regulating H3K27me3 and activating the PI3K/AKT/NF-κB pathway42, which is considered a checkpoint for R-CHOP resistance in DLBCL; PI3K/AKT inhibition was found to reverse R-CHOP resistance by destabilizing SOX2 in DLBCL43.