The majority of DLBCL patients present a double rearrangement of MYC and BCL2 genes called double-hit lymphoma (DHL), a chromosomal breakpoint, affecting the MYC/8q24 locus in combination with another recurrent breakpoint, usually BCL2 [t(14;18)(q32;q21)], although BCL6/MYC-positive DHLs or BCL2/BCL6/MYC-positive triple-hit lymphomas (THLs) may also be observed. This evidence concerns the gene BCL6 and diffuse large B-cell lymphoma.