When analyzing the genetic alterations of patients with localized PCa from the TCGA-PRAD data set with gene amplification for YWHAZ, there was a significantly higher number of altered genes per patient with YWHAZ amplification compared with those with unaltered YWHAZ (P < 0.001) (Fig. 6a and Supplementary Fig. 4). Here, YWHAZ is linked to prostate adenocarcinoma.