The number of CD25hi FoxP3+ CD4+ Tregs in the spleen was significantly increased in Cd19Cre+/−PtenloxP/loxP mice compared to those in Cd19Cre+/− mice during all courses of IL-23-mediated psoriasis-like inflammation and increased gradually relative to Bregs during the course of disease progression in Cd19Cre+/−PtenloxP/loxP mice (P < 0.05 and P < 0.01; Fig. 4B). This evidence concerns the gene CD4 and psoriasis.