In the spleen, the frequencies of IL-10-producing B cells was significantly increased in Cd19Cre+/−PtenloxP/loxP mice compared to those in Cd19Cre+/− mice during all courses of IL-23-mediated psoriasis-like inflammation (P < 0.05 and P < 0.001; Fig. 4A). Here, IL10 is linked to psoriasis.