INS and type 2 diabetes mellitus: In addition, lipid transport has been shown to be involved in regulating insulin secretion4, while both phenome wide association studies (PheWAS) and Mendelian randomization (MR) approaches have found that single nucleotide polymorphisms (SNPs) associated with increased risk of CAD are associated with increased LDL levels, but decreased fasting insulin levels and T2D risk5.