The first step in our integrative analysis process was to construct tissue-specific differential expression (DE) signatures correlated with traits by identifying genes whose expression was significantly correlated with the clinical measurements we had of plasma lipids (total plasma cholesterol, LDL, HDL, and triglycerides), diagnosis of hyperlipidemia, active statin therapy, blood glucose traits (plasma HbA1c, blood glucose, and insulin), diagnosis of T2D, and active oral anti-diabetic therapy. This evidence concerns the gene INS and type 2 diabetes mellitus.