To this end, we compared both IgE and IgG immunocaptures across serum samples from three groups: individuals with IgE-mediated wheat allergy (positive wheat-specific IgE testing by immunoCAP and convincing history of an acute IgE-mediated reaction during a recent home exposure or clinic wheat food challenge; N = 32), individuals with wheat “sensitivity”13 (sensitized; detectable wheat-specific IgE testing but tolerating wheat in their diet; N = 27), and non-allergics (undetectable wheat IgE and tolerating wheat in their diet; N = 27). This evidence concerns the gene IGHE and wheat allergic reaction.