Notably, a UGCAUG consensus site for RBFOX2 binding is located just 12 nt downstream of this exon and evaluation of ENCODE eCLIP data for the CML cell line K562 revealed direct association of RBFOX2 to exon 23 of PTK2B (Fig. 10f). Here, PTK2B is linked to chronic myelogenous leukemia, BCR-ABL1 positive.