Evaluation of infection-induced changes in CD4 T-cell differentiation at Day 7 revealed a strong phenotypic shift to Th1 effectors (CXCR3+), Th1 polarized Tfh cells (CXCR3+ CXCR5+) and Th1 Th17 (CXCR3+ CCR6+) CD4 T cells as demonstrated by tSNE plots constructed using flow data (Fig. 3D, Figure S2A). This evidence concerns the gene CD4 and infection.