Moreover, germline mutations in BAP1 have also been associated with BAP1-tumor predisposition syndrome that consists of multiple tumors, such as the following in descending order of frequency: uveal melanoma (UM), malignant mesothelioma (MMe), cutaneous melanoma (CM), clear cell renal cell carcinoma (ccRCC), and basal cell carcinoma (BCC)68,69. The gene discussed is BAP1; the disease is uveal melanoma.