In addition, the tumor-promoting effect of circ-NOLC1 was reduced after ESRP1, CDK1, or RhoA knockdown in circ-NOLC1-overexpressing cells, thus we hypothesized that circ-NOLC1 might function as an oncogene through binding and modulating ESRP1, CDK1, and RhoA levels. Here, ESRP1 is linked to neoplasm.