PTBP1 and leukemia: Recently, Sun et al.31 reported that circMYBL2 regulates the translation efficiency of oncogene FLT3 mRNA by recruiting RNA-binding protein PTBP1, thereby promoting the occurrence and development of FLT3-ITD mutant leukemia, which demonstrated for the first time that circRNA could play a positive regulatory role in the translation process in the form of an RNA-protein complex.