mRNA expression levels of TLR2 (p = 0.023), ZFP36 (p = 0.031), ELK1 (p = 0.004), HES5 (p = 0.014), and ASPDH (p = 0.015) were significantly changed in MDD subjects as shown in Fig. S2B. This evidence concerns the gene TLR2 and major depressive disorder.