The geometric means (GAPDH, ACTB, and 18s rRNA) were not significantly different between control and MDD groups in both total (t = 1.324, d.f. = 28, p = 0.196) and synaptic (t = 0.906, d.f. = 28, p = 0.373) fractions. This evidence concerns the gene GAPDH and major depressive disorder.