To further confirm the involvement of CSN6 in melanoma proliferation and metastasis, CSN6 expression was recovered through transfection of a full-length CSN6 sequence resistant to shRNA#1 targeting into CSN6-knockdown melanoma cells, and the results showed that CSN6 protein and messenger RNA (mRNA) expression levels were successfully recovered (Fig. 3A). Here, COPS6 is linked to melanoma.