These two studies attributed the “pro-oncogenic” role of SIRT6 in BC not only to the ability of SIRT6 to promote DNA repair in BC cells and, consequently, to mediate resistance to chemotherapeutics, but also to the increased expression of MMP9, β-catenin, CCND1, and NF-κB and to enhanced BC cell migration and invasiveness. The gene discussed is SIRT6; the disease is breast cancer.