However, in other types of malignancies, such as multiple myeloma, acute myeloid leukemia, and non-melanoma skin cancer, and in pancreatic cancer cells, SIRT6 was reported to have tumor-promoting effects thanks to its ability to enhance tumor DNA repair, secretion of pro-inflammatory and pro-angiogenic factors, Ca2+ signaling, cell migration, and cancer cell de-differentiation [12–15]. Here, SIRT6 is linked to pancreatic neoplasm.