The three novel MET, FGFR4, and ERBB3 isoforms were predicted to be initiated from promoters distinct from their annotated TSSs (51 kb away (MET), 438 bp (FGFR4), 248 bp (ERBB3), and upregulated in tumor samples to a greater degree from their known isoforms (Fig. 5e). The gene discussed is MET; the disease is neoplasm.