The proposed pro-cancer roles of PKM2 lead to the discovery of specific and allosteric PKM2 activators, e.g., DASA-58 and TEPP-46, as both compounds showed an enhanced pyruvate kinase (PK) activity only in cells expressing PKM2 while exhibiting no or very low activity in case of PKM1 or other PK isozymes [20]. Here, PKM is linked to cancer.