IL33 and inflammatory bowel disease: Although none of these studies reported on the role of IL-33 in the development of intestinal pathology, studies related to inflammatory bowel diseases have found controversial roles for IL-33 in the development and/or exacerbation of these diseases, with some reporting a protective role for IL-33 [41] and others incriminating it in the development or exacerbation of these diseases [42, 43].