While studies related to inflammatory bowel diseases have reported controversial roles for IL-33 in the development and/or exacerbation of these diseases, with some reporting a protective role for IL-33 [31, 41] and others incriminating it in the development or exacerbation of these diseases [42, 43], to the best of our knowledge there has been no report on the role of this cytokine in intestinal pathology during schistosomiasis. The gene discussed is IL33; the disease is schistosomiasis.