The involvement of SASP in AMD has clinical manifestation too, as a number of inflammatory cytokines have been uncovered to be elevated either systemically in the sera or locally in the aqueous humor of patients with AMD, particularly IL-6, IL-8, IL-12, MCP-1, TNF-α, IL-1α, IL-1β, and IL-17 [82, 123, 131]. The gene discussed is TNF; the disease is age-related macular degeneration.