For example, premature senescence of retinal ganglion cells in mice can be induced by experimental ocular hypertension (a model of glaucoma), and an early removal of senescent ganglion cells and their SASP secretion in p16-3MR transgenic mice subjected to ocular hypertension prevents disease progression by rescuing surrounding healthy cells [75]. The gene discussed is CDKN2A; the disease is ocular hypertension.