ARHGAP10 and Cognitive impairment: One possible explanation for the higher sensitivity of Arhgap10 S490P/NHEJ mice to methamphetamine-induced cognitive impairment in the visual discrimination task as well as methamphetamine-induced hyperlocomotion [13], is that methamphetamine-induced DA release may be potentiated in Arhgap10 S490P/NHEJ mice compared with wild-type mice.