Lipid loaded mature adipocyte-secreted exosomes transport miR-34a to macrophage and suppress anti-inflammatory M2 phenotype by repressing Kruppel-like factor 4 (Klf-4) [86] Mir-34a is key mediator in exacerbating obesity related systemic inflammation and metabolic dysregulation [86] As contrary, previous studies reported that miR-34a were downregulated in human breast tissue [87]. Here, KLF4 is linked to obesity due to melanocortin 4 receptor deficiency.