TOP1 and nervous system disorder: Among the above targets, DNA polymerase kappa, DNA topoisomerase 1, Carbonic anhydrase 7, Glucocorticoid receptor, Lysine N-methyltransferase 6 and Vitamin D3 receptor are related to tumor, arinic acetylcholine receptor M1 is related to neurological diseases, Replicase polyprotein 1a is relataed to virus and thioredoxin glutathione reductase is an essential parasite enzyme [79–86].