For the above predicted targets, Arachidonate 5-lipoxygenase, DNA topoisomerase 2-alpha, M-phase inducer phosphatase 2 and retinoic acid receptor RXR-alpha are related to tumor, integrase is an important target for virus, is related to skin diseases, and UCH-L1 is related to neurological diseases [88–93]. Here, TOP2A is linked to nervous system disorder.