The remaining 12 SMGs (HEATR5B, KIF24, ANKRD17, AACS, MYEF2, GXYLT1, CCDC71, EPB41L2, GPS1, SLC44A3, INSIG2, and RPUSD2) have no known role in other cancers but are found mutated in cSCC in the Catalogue Of Somatic Mutations In Cancer database. This evidence concerns the gene RPUSD2 and skin squamous cell carcinoma.