Genes previously implicated in cSCC, such as CDKN2A and HRAS, were found altered at similar rates between our AK and cSCC cohorts (54.1% and 45% altered for CDKN2A, respectively, and 16.2% and 22.5% altered for HRAS, respectively; Supplementary Table S18). This evidence concerns the gene CDKN2A and skin squamous cell carcinoma.