Interestingly, it was found that NXQ (nitroxoline) can suppress cell viability and induce apoptosis by downregulating TRIM25,[221] whose role in cancer development through regulation of p53 stability was previously reported.[222] However, the precise mechanism remains unclear, since it is unknown whether NXQ can influence TRIM25 transcription and/or expression or affect the ligase activity. Here, TRIM25 is linked to cancer.