For instance, in the treatment of cancer, as members of this family can modulate the stability and function of important regulators of carcinogenesis through their ubiquitylation activity, driving cell cycle progression or apoptosis, proliferation or differentiation, respectively.[56] Additionally, there are several examples of TRIM proteins that function as nuclear receptors and transcription co‐activators/co‐repressors of oncogenic pathways.[56] Importantly, some TRIMs are encoded by genes involved in specific cancer‐related chromosomal re‐arrangements. This evidence concerns the gene TRAT1 and cancer.