Finally, the ROC curve analysis demonstrated that, when setting a cut-point of 8 points, the PCT-based score had a good sepsis-detecting ability of the (AUROC 0.80, 95%CI 0.74–0.85, sensitivity 0.70, specificity 0.76), which were significantly better than the PCT level alone (p = 0.020), CRP (p<0.001), and IPS (p<0.001) (Fig 1, Table 5(A) and S2 Table) The Hosmer and Lemeshow test confirmed the adequate calibration of the proposed model (goodness-of-fit statistic 4.10 with 8 degrees of freedom, p = 0.848). This evidence concerns the gene CRP and Sepsis.