Its humanized counterpart JC-7U IgG1 has been reported to inhibit tumor growth in a Kaposi sarcoma mouse model and was also able to inhibit, in part, the binding of human immunodeficiency virus (HIV-1) Tat protein to αVβ3 integrin, which is necessary to stimulate Kaposi sarcoma growth [16, 53]. Here, TAT is linked to Kaposi's sarcoma.