Therefore, next, we tested the relationship between patients’ survival and the methylation level of CpG island in the promoter region of PTENP1. We analyzed the TCGA methylome data obtained from 431 patients with endometrial carcinoma, 261 patients with sarcoma, 194 patients with acute myeloid leukemia and 515 patients suffering from lower grade glioma. This evidence concerns the gene PTENP1 and central nervous system cancer.