FURIN and depressive symptom measurement: This highlighted pleiotropic loci such as FURIN [initially implicated in schizophrenia risk (P = 1.05 × 10−7)], which had evidence of an effect on 28 other outcomes, as well as genes which may have a more specific role in disease pathogenesis [e.g. SLC12A5 which only provided evidence of an effect on depression (P = 7.13 × 10−10)].