CLCN3 and depressive symptom measurement: This included genes whose genetically predicted expression was associated with schizophrenia, such as CLCN3 (P = 5.99 × 10−7) and ABCB6 (P = 9.48 × 10−7) and SLC12A5, which was associated with depression (P = 7.30 × 10−10, Fig. 4B), serine protease 36 (PRSS36) which was associated with Alzheimer’s disease (P = 7.30 × 10−8) and neuromedin B (NMB) which was associated with bipolar disease (P = 1.70 × 10−6, Fig. 4C).