PRSS36 has been implicated via eQTL association in the hippocampus, which is highly affected early in Alzheimer’s disease. Furthermore, a summary-based tissue-specific transcriptome-wide association study (77) using a factor polygenic QTL analysis, jointly modelling gene expression across tissues and individuals, found brain-specific expression of PRSS36 to be associated with Alzheimer’s disease. This evidence concerns the gene PRSS36 and early-onset autosomal dominant Alzheimer disease.