SLC12A5 and major depressive disorder: This included genes such as SLC12A5, which showed evidence of a genetically predicted effect on depression and neuroticism (P = 7.13 × 10−10 and P = 2.10 × 10−9 respectively), as well as PCDHA8, which provided evidence of genetically predicted effect on schizophrenia risk (P = 6.04 × 10−6).