A previous integrative analysis using a different brain eQTL and mQTL dataset found that the expression of the SLC12A5 colocalized the risk of neuroticism (78). Furthermore, it has been reported to increase the risk of other brain-related disorders, such as epilepsy (79). Changes in SLC12A5 expression were not identified as conferring risk to MDD in a Sherlock analysis (80), integrating the genetic associations from a MDD GWAS (42) and brain eQTL dataset (46). The SLC12A5 gene encodes a neuron-specific transmembrane cotransporter (81), which plays a role in mediating fast synaptic inhibition. Here, SLC12A5 is linked to epilepsy.