In addition, this peptide is well known for its specific capacity to stimulate Gh production/secretion in GH3 and adenoma cells and in in vivo approaches (Matsushita et al. 1981, Chihara et al. 1982, Denef et al. 1985, Bluet-Pajot et al. 1987, Murakami et al. 1995, Fazekas et al. 2000). This evidence concerns the gene GH1 and adenoma.