PTCH1 and acromegaly: For example patients and mice with heterozygous PTCH/Ptch germline mutation occasionally develop acromegaly-like symptoms (Kahn & Gordon 1967, Codish et al. 1973, Marcos et al. 1982, Cramer & Niederdellmann 1983, Bale et al. 1991, 1994, Kimonis et al. 1997, Wicking et al. 1997, Hahn et al. 1998, Lo Muzio et al. 1999).