Given that chronic TNF‐α exposure suppresses T‐cell receptor signaling (Cope et al., 1997), blocking TNF‐α enhances CD8+ T‐cell responses in murine models of melanoma (Bertrand et al., 2015), and TNF‐α/PD‐1 gene expression levels are positively correlated in patients with melanoma (Bertrand et al., 2017), we determined whether IL‐37 antagonized TNF‐α signaling in aged T‐cells. This evidence concerns the gene TNF and melanoma.