PDCD1 and melanoma: Given that chronic TNF‐α exposure suppresses T‐cell receptor signaling (Cope et al., 1997), blocking TNF‐α enhances CD8+ T‐cell responses in murine models of melanoma (Bertrand et al., 2015), and TNF‐α/PD‐1 gene expression levels are positively correlated in patients with melanoma (Bertrand et al., 2017), we determined whether IL‐37 antagonized TNF‐α signaling in aged T‐cells.