MKK7 is a sensor of cellular stress, particularly associated with onogenesis.80 While MKK7 is implicated in T-cell acute lymphoblastic leukaemia, myeloma and lung cancers, its functions are context dependent and can be involved in cancer progression but also act as a tumour suppressor in many instances.80,81 Consequently, the development of MKK7 inhibitors has not been extensively studied, and no MKK7-inhibitors have entered clinical trials. This evidence concerns the gene MAP2K7 and plasma cell myeloma.