HGF and cancer: While under normal conditions mediates the wound healing response, abnormal cMET activation can promote the development and progression of multiple cancers.64 The HGF/cMET signalling cascade can stimulate downstream pathways implicated in cancer progression, such as PI3K/AKT, JAK/STAT, RAS/MAPK and SRC, which are responsible for regulating proliferation, invasion, metastasis and other hallmarks of cancer.