Given the observation that NOTCH3 has prognostic value in GC, the RNA expression data in The Cancer Genome Atlas (TCGA) database were also used to analyze the prognostic potential of NOTCH3 in other gastrointestinal (GI) cancers, including LIHC, ESCA, COAD, and PAAD. The gene discussed is NOTCH3; the disease is pancreatic adenocarcinoma.