Bulk RNA-sequencing profiling showed that ACE2 and TMPRSS2 were expressed at higher levels in human colorectal tumor and normal tissue samples than in human tumor or normal tissue samples of lung, esophagus, stomach, and liver (P for all <0.05, Fig. 1), indicating that the colorectum may be a likely route of infection with SARS-CoV-2 in addition to the lungs. This evidence concerns the gene TMPRSS2 and colorectal neoplasm.