Presumably, the adaptive immune response against TDP-43 inclusions contemplates the production of polyclonal antibodies, as already demonstrated in DAMPs associated to a variety of neurodegenerative disorders, such as beta-amyloid for Alzheimer’s disease (AD) and alpha-synuclein for Parkinson’s disease8,9. Here, TARDBP is linked to early-onset autosomal dominant Alzheimer disease.