Our study showed that there was no significant differences in age, gender, patients with hypertension at diagnosis, patients with diabetes mellitus at diagnosis, patients with cardiovascular diseases at diagnosis, the level of ESR, hemoglobin, serum albumin, 24 h-proteinuria, urine RBC, complement C3, complement C4, HDL-C, LDL-C, anti-MPO, anti-PR3 and BVAS between patients with and without hyperuricemia. The gene discussed is ESR1; the disease is diabetes mellitus.