We also found that hyperuricemia was an independent predictor of poor patients and renal survival over a follow-up 12 months, even after adjustment for the covariates including systolic blood pressure, diastolic blood pressure, serum creatinine, eGFR, total cholesterol, triglycerides, CRP, the proportion of normal glomeruli, crescent, fibrous crescent and so on. The gene discussed is CRP; the disease is hyperuricemia.