Cxcl11 (C-X-C Motif Chemokine Ligand 11) was a potent and physiologic inducer of Cxcr3 internalization after T cell contact with activated endothelial cells as reported and it could also induce calcium release in activated T-cells, thus, it might be necessary in central nervous system diseases concerning T-cell recruitment and immune responses in skin19. This evidence concerns the gene CXCR3 and central nervous system disorder.