The degradation of maternal RNAs in D. melanogaster is mostly guided by the protein products of a group of genes comprising smaug (RPRC007649), brain tumor (RPRC007254), not1 (RPRC005691), not3 (RPRC003870), not10 (RPRC001957), cnot4 (RPRC001525), pop2 (RPRC004491), regena (RPRC003111), caf1 (RPRC015316), early girl (RPRC004083), wispy (RPRC007755), twin/CCR4 (RPRC006991), and string (RPRC008472)80–85. Here, CNOT4 is linked to brain neoplasm.