ACE2 and Dravet syndrome: We found ACE2 (Fig. 3B) upregulated in DS human induced pluripotent stem cells (iPSCs) 34, downregulated in peripheral blood from DS individuals39; slightly upregulated in the hippocampus of the DS model Ts1Cje (6–7 months old)40, DS human postnatal inferior temporal cortex32 and adult dorsolateral prefrontal cortex32, and slightly downregulated in post-mortem dorsolateral DS prefrontal cortex41.