AQP4 and major depressive disorder: There were no significant differences in concentrations of AQP4 and GFAP-positive EVs and EVs co-expressing AQP4/GFAP between patients with SED or MDD who received antidepressant medication (n=49) and patients with SED or MDD who did not receive such medication (n=10, missing data=3) (data not shown).