Some examples such as measurement of albumin excreted in the urine, Excretion of urinary non-albumin proteins, increased urinary transferrin, estimation of Kidney injury molecule 1 (KIM-1), increased Fibronectin (FN), increased levels of Retinol-binding protein (RBP), Redox-regulating protein p66Shc, Apolipoproteins and some Serum/plasma biomarkers, etc. However, by considering the sensitivity/accuracy of results still there is an emerging/novel approach such as therapeutic or diagnostic are highly desired to conquer the CKD at earlier stages. This evidence concerns the gene ALB and chronic kidney disease.