For example, one relevant cluster was composed of cytokines CCL20, CX3CL1, CXCL13, IL-15, IL-22 and IL-6 (Module 1, green in Fig. 3, values shown in Supplementary Table S4), which have been already proposed as candidate modulators of lymphocyte infiltration into the brain and may contribute to cognitive impairment in MHE3. This evidence concerns the gene IL22 and Cognitive impairment.