DNAJC5 and malaria: Although the monoclonal-like response conferred by the single epitope displaying CIS43 VLPs did not confer sterilizing immunity against malaria in a mouse challenge model, the degree of protection elicited by this vaccine highlights the importance of this particular epitope for future clinical applications, and the potential efficacy of additional VLP-based vaccines that target critical epitopes within the junctional region of CSP.