The Valosin-Containing Protein (VCP) gene encodes an AAA+ ATPase1 that has been linked to a broad spectrum of autosomal dominant degenerative diseases including IBMPFD (inclusion body myopathy with Paget’s disease and fronto-temporal dementia; Watts et al.2), amyotrophic lateral sclerosis (ALS)3,4, spastic paraplegia5, muscular dystrophy6, and Parkinson’s disease7,8. This evidence concerns the gene VCP and inclusion body myopathy with Paget disease of bone and frontotemporal dementia.