VCP and Paget disease: The Valosin-Containing Protein (VCP) gene encodes an AAA+ ATPase1 that has been linked to a broad spectrum of autosomal dominant degenerative diseases including IBMPFD (inclusion body myopathy with Paget’s disease and fronto-temporal dementia; Watts et al.2), amyotrophic lateral sclerosis (ALS)3,4, spastic paraplegia5, muscular dystrophy6, and Parkinson’s disease7,8.